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P9156

Sigma-Aldrich

Plasminogen from bovine plasma

lyophilized powder, ≥2.0 units/mg protein

Synonym(s):

Profibrinolysin

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About This Item

CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352202
eCl@ss:
42030240
NACRES:
NA.61

biological source

bovine plasma

Quality Level

form

lyophilized powder

specific activity

≥2.0 units/mg protein

concentration

2-7% protein (biuret)

suitability

not suitable for streptokinase determination by clot formation procedure

UniProt accession no.

application(s)

histology

storage temp.

2-8°C

Gene Information

cow ... PLG(280897)
human ... PLG(5340)

Biochem/physiol Actions

Plasminogen is the inactive precursor of the protease plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration. Plasmin cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. It is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).
The activated form of plasminogen, plasmin, was shown to promote the migration of melanoma and lung tumor cells plated on the extracellular matrix protein laminin by altering protein kinase C signaling.

Other Notes

ε-Aminocaproic acid free

Unit Definition

One unit will produce 1.0 μmole of p-nitroanilide from D-Val-Leu-Lys 4-nitroanilide at pH 7.5 at 37°C.

Physical form

Lyophilized powder containing NaCl, EDTA, lysine, and Tris buffer salts

Reconstitution

Solutions should be stored in buffer containing 20 mM lysine at neutral pH. The protein should be as concentrated as possible. Frozen in aliquots at −20 °C, it should be stable for several weeks.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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