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P9864

Sigma-Aldrich

PTP-β human

≥90%, recombinant, expressed in E. coli K12, GST-tagged, buffered aqueous glycerol solution, ≥50,000 units/mg protein

Synonym(s):

Protein Tyrosine Phosphatase-β

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

Quality Level

recombinant

expressed in E. coli K12

Assay

≥90%

form

buffered aqueous glycerol solution

specific activity

≥50,000 units/mg protein

mol wt

~250 kDa

UniProt accession no.

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PTPRB(5787)

General description

Protein tyrosine phosphatase, receptor type B (PTPRB), also known as vascular endothelial-protein-tyrosine phosphatase (VE-PTP), might have a role in remodeling of blood vessels and in angiogenesis. The gene encoding it is localized on human chromosome 12q15. It is also important for endothelial cell migration. The protein also controls the phosphorylation state of the angiopoietin receptor, Tie-2. PTPRB may modulate sodium channels by influencing the tyrosine phosphorylation status.

Biochem/physiol Actions

Dephosphorylates tyrosine proteins.

Unit Definition

One unit of PTP-β will hydrolyze 1.0 nanomole of p-nitrophenyl phosphate per min at 30 °C.

Physical form

solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCL, 3 mM DTT, 16 mM glutathione and 20% glycerol

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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