PZ0135

PHA-543613

≥98% (HPLC)

• Synonym(s): N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide
• Empirical Formula (Hill Notation): C₁₅H₁₇N₃O₂
• CAS Number: 478149-53-0
• Molecular Weight: 271.31
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823720
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: ≥20 mg/mL
• storage temp.: room temp
• SMILES string: O=C(N[C@H]1CN2CC[C@H]1CC2)c3cc4ccoc4cn3
• InChI: 1S/C15H17N3O2/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19)/t13-/m0/s1
• InChI key: IPKZCLGGYKRDES-ZDUSSCGKSA-N
• Gene Information: human ... CHRNA7(1139)

Description

Application

PHA-543613 has been used to study its effect on recognition memory and neurovascular coupling (NVC) response in β-amyloid (Aβ) 25-35-treated mice. It has also been used to study its effect on Aβ25-35-induced receptor alteration and cognitive impairment in mice.

Biochem/physiol Actions

PHA-543613 exhibits rapid brain penetration property.

PHA-543613 is a potent selective α7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression in brain. The homomeric subtype α7 is a potential therapeutic target for cognitive deficits in schizophrenia and Alzheimer′s disease. PHA-543613 is active in both in vitro (binding, calcium flux, patch-clamp) and in vivo (auditory gating, novel object recognition) assays.

PHA-543613 is a potent selective a7 nAChR agonist.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable