PZ0160

UK-5099

≥98% (HPLC), powder, mitochondrial pyruvate carrier inhibitor

• Synonym(s): 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, PF-1005023
• Empirical Formula (Hill Notation): C₁₈H₁₂N₂O₂
• CAS Number: 56396-35-1
• Molecular Weight: 288.30
• MDL number: MFCD19443867
• UNSPSC Code: 12352200
• PubChem Substance ID: 329823742
• NACRES: NA.77

Properties

• Product Name: UK-5099, ≥98% (HPLC)
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: yellow to tan
• solubility: DMSO: >20 mg/mL
• storage temp.: 2-8°C
• SMILES string: OC(=O)\C(=C\c1cn(-c2ccccc2)c3ccccc13)C#N
• InChI: 1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+
• InChI key: BIZNHCWFGNKBBZ-JLHYYAGUSA-N

Description

Application

UK-5099 has been used:

• as a mitochondrial pyruvate blocker to reduce pyruvate transportation into mitochondria in Roswell park memorial institute (RPMI) 1640 medium for prostatic cancer cell line culture
• in dimethyl sulfoxide (DMSO) stock, to study the effect of inhibiting pyruvate transport into mitochondria on pro-inflammatory responses in lipopolysaccharide activated macrophages
• in topical treatment in order to study its effect on hair cycle induction in experimental mice

Biochem/physiol Actions

UK-5099 induces lactate generation.

UK-5099 is a potent inhibitor of the mitochondrial pyruvate transporter.

UK-5099 is a potent inhibitor of the mitochondrial pyruvate transporter. In rat heart mitochondria, UK-5099 inhibits pyruvate-dependent O₂ consumption with an IC₅₀ of 50 nM.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable