R2033

RK-682

≥98% (HPLC)

• Synonym(s): (R)-3-Hexadecanoyl-5-hydroxymethyltetronic acid, (R)-4-Hydroxy-5-(hydroxymethyl)-3-(1-oxohexadecyl)-2(5H)-furanone
• Empirical Formula (Hill Notation): C₂₁H₃₆O₅
• CAS Number: 150627-37-5
• Molecular Weight: 368.51
• MDL number: MFCD20488046
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824012
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO, heptane and xylene: ≥8 mg/mL
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCCCCCC(=O)C1=C(O)[C@@H](CO)OC1=O
• InChI: 1S/C21H36O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(23)19-20(24)18(16-22)26-21(19)25/h18,22,24H,2-16H2,1H3/t18-/m1/s1
• InChI key: KZTSLHQKWLYYAC-GOSISDBHSA-N

Description

Application

RK-682 has been used:

• as a positive control in high-performance liquid chromatography (HPLC)
• as a reference compound in high-performance liqiud chromatography (HPLC)
• as a pan-protein tyrosine phosphatase non-receptor type (PTPN) inhibitor to study its effects on the activated lymphocytes

Biochem/physiol Actions

RK-682 is a specific and noncompetitive inhibitor of protein tyrosine phosphatase; It inhibited dephosphorylation activity of CD45 and VHR with IC50 54 and 2.0 microM and 4.5 microM against PTP1B.

Specific and noncompetitive inhibitor of protein tyrosine phosphatase.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable