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S0439

Sigma-Aldrich

SUMO-1 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli (GST-tagged)

Synonym(s):

Sentrin-1

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About This Item

MDL number:
UNSPSC Code:
12352202
NACRES:
NA.32

recombinant

expressed in E. coli (GST-tagged)

Quality Level

Assay

≥95% (SDS-PAGE)

mol wt

38.5 kDa

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... SUMO1(7341)

General description

Small ubiquitin-like modifier 1 (SUMO-1), a protein, is one of the 5 SUMO paralogs expressed in mammalian cells with a low but significant homology with ubiquitin. This SUMO-1-GST fusion protein is produced from a DNA sequence corresponding to human SUMO-1 fused to a glutathione S-transferase (GST)-tag and is expressed in E. coli cells.

Application

SUMO-1 human has been used in pre-absorption for negative immunostaining to confirm the specificity of the small ubiquitin like modifier 1 (SUMO-1) antibody.

Biochem/physiol Actions

Conjugated to a variety of proteins by UbcH9, including RanGAP1, IκBα, and PML without the requirement of an equivalent E3 ubiquitin ligase.
Small ubiquitin-like modifier 1 (SUMO-1) plays a key role in modulating survival, migration, and signal transduction in some cell lines. It can prevent in vitro migration and invasion of RA fibroblast-like synoviocytes (FLSs). Higher expression of SUMO-1 may result in joint destruction in rheumatoid arthritis (RA).

Physical form

Solution in 50 mM HEPES, pH 8.0, 150 mM NaCl and 1 mM DTT.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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