S166

Saclofen

solid

• Synonym(s): β-(Aminomethyl)-4-chlorobenzeneethanesulfonic acid
• Empirical Formula (Hill Notation): C₉H₁₂ClNO₃S
• CAS Number: 125464-42-8
• Molecular Weight: 249.71
• MDL number: MFCD00216817
• UNSPSC Code: 51111800
• PubChem Substance ID: 329824485
• NACRES: NA.32

Properties

• form: solid
• Quality Level: 200
• color: white
• solubility: 0.1 M NaOH: 20 mg/mL
• SMILES string: NCC(CS(O)(=O)=O)c1ccc(Cl)cc1
• InChI: 1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)
• InChI key: JYLNVJYYQQXNEK-UHFFFAOYSA-N
• Gene Information: human ... GABBR1(2550), GABBR2(9568) ; mouse ... GABBR1(54393), GABBR2(242425) ; rat ... GABBR1(81657), GABBR2(83633)

Description

Application

Saclofen has been used as a GABA_B receptor antagonist to study the analgesic effect of repeated injections of oxycodone in rats.

Saclofen has been used to prevent the inhibitory action of oxytocin on capsaicin-induced glutamatergic spontaneous excitatory transmission in rat neurons.

Biochem/physiol Actions

Saclofen is the sulphonic analog of baclofen and is a selective GABA_B receptor antagonist.

Saclofen might possess sympathetic nervous system-dependent anti-inflammatory action.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves