S5567

SP600125

≥98% (HPLC), powder or solid, JNK inhibitor

• Synonym(s): 1,9-Pyrazoloanthrone, Anthrapyrazolone
• Empirical Formula (Hill Notation): C₁₄H₈N₂O
• CAS Number: 129-56-6
• Molecular Weight: 220.23
• EC Number: 204-955-6
• MDL number: MFCD00022289
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278395
• NACRES: NA.77

Properties

• Product Name: SP600125, ≥98% (HPLC)
• Quality Level: 200
• Assay: ≥98% (HPLC)
• color: yellow
• solubility: DMSO: 20 mg/ml, clear to very slightly hazy, faintly yellow to yellow; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: O=C1c2ccccc2-c3n[nH]c4cccc1c34
• InChI: 1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
• InChI key: ACPOUJIDANTYHO-UHFFFAOYSA-N
• Gene Information: human ... JUN(3725), MAPK10(5602), MAPK9(5601)

Description

Application

C2C12 myoblasts were treated with SP600125 to test the stimulation of myogenesis.¹¹ It was used to treat HepG2 cells to test the effects on oxysterol-induced necrosis.¹²

Biochem/physiol Actions

A novel and selective inhibitor of c-Jun N-terminal kinase (JNK)

SP600125 is an anthrapyrazolone inhibitor of JNK that competes with ATP to inhibit the phosphorylation of c-Jun. It prevents the activation of inflammatory genes such as COX-2, IL-2 IFN-γ and TNF-α.^8,9 It prevents the activation of JNK after brain ischemia and may be effective in treatment of ischemic stroke.¹⁰

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves