S8951

SR11237

≥98% (HPLC)

• Synonym(s): 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoic acid, BMS 188649, BMS649
• Empirical Formula (Hill Notation): C₂₄H₂₈O₄
• CAS Number: 146670-40-8
• Molecular Weight: 380.48
• MDL number: MFCD00864137
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824615
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: >28 mg/mL (warmed)
• storage temp.: 2-8°C
• SMILES string: CC1(C)CCC(C)(C)c2cc(ccc12)C3(OCCO3)c4ccc(cc4)C(O)=O
• InChI: 1S/C24H28O4/c1-22(2)11-12-23(3,4)20-15-18(9-10-19(20)22)24(27-13-14-28-24)17-7-5-16(6-8-17)21(25)26/h5-10,15H,11-14H2,1-4H3,(H,25,26)
• InChI key: ZZUKALQMHNSWTK-UHFFFAOYSA-N

Description

Application

SR11237 may be used in RXR-mediated cell signaling studies.

Biochem/physiol Actions

SR11237 and other ligands of retinoid X receptor (RXR) activate various nuclear receptors during development process. This produces malformations in Xenopus embryos, involving the anterior-posterior axis.¹

SR11237 is a pan retinoid X receptor (RXR) agonist.

SR11237 is a selective pan retinoid X receptor (RXR) agonist with no retinoid A receptor (RAR) activity.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable