S9576

SR8278

≥98% (HPLC)

• Synonym(s): 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
• Empirical Formula (Hill Notation): C₁₈H₁₉NO₃S₂
• CAS Number: 1254944-66-5
• Molecular Weight: 361.48
• MDL number: MFCD18782736
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824626
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: lyophilized powder
• color: white
• solubility: DMSO: ≥30 mg/mL
• storage temp.: 2-8°C
• SMILES string: CCOC(=O)C1Cc2ccccc2CN1C(=O)c3ccc(SC)s3
• InChI: 1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3
• InChI key: UIEBLUZPSFAFOC-UHFFFAOYSA-N

Description

Application

SR8278 has been used as a nuclear receptor subfamily 1, group D, member 1 (NR1D1) antagonist to study its effects on starvation-induced macrophages.

SR8278 was used as rev-erb alpha antagonist to study the regulation of glucagon secretion in mouse pancreatic alpha cells¹ and beta cells.²

Biochem/physiol Actions

SR8278 is a Nuclear Heme Receptor REV-ERB antagonist.

SR8278 is a Nuclear Heme Receptor REV-ERB antagonist. REV-ERBα plays a critical role in regulation of the circadian rhythm by repressing target gene activities. Additionally, REV-ERBα has been shown to regulate metabolic processes including lipid and glucose metabolism. SR8278 blocks the ability of the synthetic agonist GSK4112 to enhance REV-ERBα-dependent repression and stimulates the expression of REV-ERBα target genes involved in gluconeogenesis.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable