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SAE0004

Sigma-Aldrich

Kynurenine 3-Monooxygenase, Pseudomonas fluorescens (strain 17400), Recombinant

Synonym(s):

KMO

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1 EA
CA$2,610.00

About This Item

EC Number:
1.14.13.9 (BRENDA, IUBMB)
UNSPSC Code:
12352204
NACRES:
NA.54

CA$2,610.00

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form

solution

Quality Level

200

specific activity

≥3 U/mg

mol wt

50,712 Da

shipped in

dry ice

storage temp.

−70°C

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particle size

10-15 nm

particle size

8-16 nm

particle size

8-16 nm

particle size

8-16 nm

form

dispersion

form

dispersion

form

dispersion

form

dispersion

concentration

2.5 wt. % (crystalline ZnO in 2-propanol)

concentration

2.5 wt. % (crystalline ZnO in isopropanol)

concentration

2.5 wt. % (crystalline ZnO in isopropanol and propylene glycol)

concentration

2.5 wt. % (crystalline Al doped ZnO (3.15 mol% Al) in mixture of alcohols)

color

translucent yellowish

color

translucent brownish

color

translucent brownish

color

-

density

0.800 g/mL at 25 °C

density

-

density

-

density

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

General description

Kynurenine 3-monooxygenase (KMO) is a flavoprotein aromatic hydroxylase (FAH) that catalyzes the hydroxylation of L-kynurenine (L-Kyn) to produce 3-hydroxykynurenine (3-OH-Kyn). This activity is central to tryptophan metabolism and also to the production of nicotinamide adenine dinucleotide (NAD) in higher organisms. KMO contains flavin adenine dinucleotide (FAD) as a non-covalent, but tightly bound, co-factor at a 1:1 ratio of co-factor to protein.

Unit Definition

1 unit will oxidize L-kynurenine at 1 mol/min at pH 7.0, 25°C.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SLBP0511V

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Sławomir Kasperowicz et al.
IUBMB life, 72(6), 1211-1219 (2020-03-13)
A series of chlorine-substituted benzotriazole derivatives, representing all possible substitution patterns of halogen atoms attached to the benzotriazole benzene ring, were synthetized as potential inhibitors of human protein kinase CK2. Basic ADME parameters for the free solutes (hydrophobicity, electronic properties)

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