SBR00097

Sancycline

≥95% (H-NMR), powder

• Synonym(s): 6-Demethyl-6-deoxytetracycline, Bonomycin, Norcycline
• Empirical Formula (Hill Notation): C₂₁H₂₂N₂O₇
• CAS Number: 808-26-4
• Molecular Weight: 414.41
• UNSPSC Code: 51101500

Properties

• Quality Level: 100
• Assay: ≥95% (H-NMR)
• form: powder
• color: yellow to brown
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; mycoplasma
• Mode of action: protein synthesis | inhibits
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C(=CC=C4)O)C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O
• InChI: 1S/C21H22N2O7/c1-23(2)15-10-7-9-6-8-4-3-5-11(24)12(8)16(25)13(9)18(27)21(10,30)19(28)14(17(15)26)20(22)29/h3-5,9-10,15,24-25,28,30H,6-7H2,1-2H3,(H2,22,29)/t9-,10-,15-,21-/m0/s1
• InChI key: MTCQOMXDZUULRV-ADOAZJKMSA-N

Description

General description

Sancycline is an antibioitic which belongs to the class of compounds known as tetracycline antibiotics. It is a semisynthetic derivative of naturally occurring tetracycline and is used in the treatment of bacterial infections caused by susceptible organisms. Sancycline is active against a wide range of Gram-positive and Gram-negative bacteria, as well as atypical bacteria such as Mycoplasma and Chlamydia species.

Biochem/physiol Actions

Sancycline inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome. Specifically, it binds to the A site of the ribosome and blocks the attachment of aminoacyl-tRNA molecules to the ribosome, which is necessary for the addition of new amino acids to the growing polypeptide chain. This ultimately leads to the inhibition of bacterial protein synthesis and bacterial death.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable