SCP0157

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP)

• Synonym(s): GRGDSP Peptide, RGD Peptide
• Empirical Formula (Hill Notation): C₂₂H₃₇N₉O₁₀
• Molecular Weight: 587.58
• UNSPSC Code: 12352209
• NACRES: NA.32

Properties

• Assay: ≥95% (HPLC)
• form: lyophilized
• composition: Peptide Content, ≥60%
• storage condition: protect from light
• storage temp.: −20°C

Description

Amino Acid Sequence

Gly-Arg-Gly-Asp-Ser-Pro

General description

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is a bioactive molecule/peptide derived from fibronectin.

Application

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) has been used:

• in coating well plate to monitor cell attachment by crystal violet staining
• to treat baby hamster kidney (BHK-21) cells to study the role of Arg-Gly-Asp (RGD) motif in the replication of Japanese encephalitis virus (JEV)
• to block RGD-dependent integrins or integrin signaling in INA-6 cells
• to study the role of the RGD-binding integrins in Gal-3-mediated cell adhesion

Biochem/physiol Actions

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) can stimulate endothelialization by modifying the surface of cardiovascular implants. The major cell- binding domain of GRGDSP helps to promote cell adhesion on a wide range of substrates.

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide. GRGDSP is used widely together with other RGD peptides in integrin research.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable