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SCP0157

Sigma-Aldrich

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP)

Synonym(s):

GRGDSP Peptide, RGD Peptide

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About This Item

Empirical Formula (Hill Notation):
C22H37N9O10
Molecular Weight:
587.58
UNSPSC Code:
12352209
NACRES:
NA.32

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥60%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Gly-Arg-Gly-Asp-Ser-Pro

General description

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is a bioactive molecule/peptide derived from fibronectin.

Application

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) has been used:
  • in coating well plate to monitor cell attachment by crystal violet staining
  • to treat baby hamster kidney (BHK-21) cells to study the role of Arg-Gly-Asp (RGD) motif in the replication of Japanese encephalitis virus (JEV)
  • to block RGD-dependent integrins or integrin signaling in INA-6 cells
  • to study the role of the RGD-binding integrins in Gal-3-mediated cell adhesion

Biochem/physiol Actions

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) can stimulate endothelialization by modifying the surface of cardiovascular implants. The major cell- binding domain of GRGDSP helps to promote cell adhesion on a wide range of substrates.
Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide. GRGDSP is used widely together with other RGD peptides in integrin research.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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