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SCP0170

Sigma-Aldrich

Granulocyte Elastase Substrate human

≥95% (HPLC), lyophilized

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CA$173.00
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CA$596.00

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100 G
CA$173.00
500 G
CA$596.00

About This Item

Empirical Formula (Hill Notation):
C21H27N5O6
Molecular Weight:
445.47
UNSPSC Code:
12352204
NACRES:
NA.32

CA$173.00


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Product Name

Granulocyte Elastase Substrate human,

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥85%

storage condition

protect from light

storage temp.

−20°C

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This Item
CDS014873CBR01504CDS000033
form

solid

form

solid

form

solid

form

solid

description

AldrichCPR

description

-

description

-

description

-

Amino Acid Sequence

Glp-Pro-Val-pNA

General description

Elastase, a glycoprotein, is a member of the serine proteases family.[1] It is synthesized by human polymorphonuclear (PMN) leukocytes or by the pancreas.[2] Human granulocyte elastase is liberated in large amounts from granulocytes in chronic inflammatory joint disorders.[3]

Biochem/physiol Actions

Elastase is a catalytic enzyme that catalyzes the cleavage of carboxyl groups on tiny hydrophobic amino acids including glycine, alanine, and valine. Its main function is to break down elastin.[4] Free elastase in some purulent synovial fluids plays a key role in articular cartilage breakdown. Increased elastase levels in the plasma have been seen in patients with evident rheumatoid arthritis.[3]
Elastase(s) can be assayed and differentiated using chromogenic and fluorogenic Pro-Val peptide substrates such as Glp-Pro-Val-pNA and MeOSuc-Ala-Ala-Pro-Val-4-MNA.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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