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Key Documents

SCP0200

Sigma-Aldrich

Neuromedin N

Synonym(s):

NMN-125, NN, NT/N, NmN

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About This Item

Empirical Formula (Hill Notation):
C38H63N7O8
Molecular Weight:
745.95
UNSPSC Code:
12352200
NACRES:
NA.32

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥65%

storage condition

protect from light

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... NTS(4922)

Amino Acid Sequence

Lys-Ile-Pro-Tyr-Ile-Leu

Biochem/physiol Actions

Neuromedin N is a hexapeptide that is related to neurotensin. Its precursor, proneuromedin N, is expressed in the adrenals, brain, gut and also in several cancers. In myoelectric activity, it has been reported to act in a similar manner as neurotensin, at a lesser degree of potency. Neuromedin N has been shown to increase the chemotaxis capacity of mouse lymphocytes and to modulate function of the hypothalamo-pituitary-adrenocortical axis in rats. Neuromedin N has been proposed to exert its actions via increase in intracellular Ca2+ concentration, although this is uncertain.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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