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Key Documents

SML0006

Sigma-Aldrich

CK-666

≥98% (HPLC), powder, Arp2/3 comple inhibitor

Synonym(s):

2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide, CK 666, CK-0944666

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About This Item

Empirical Formula (Hill Notation):
C18H17FN2O
CAS Number:
Molecular Weight:
296.34
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Product Name

CK-666, ≥98% (HPLC), powder

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥25 mg/mL

storage temp.

2-8°C

SMILES string

Cc1[nH]c2ccccc2c1CCNC(=O)c3ccccc3F

InChI

1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)

InChI key

UXRKUKRXVWJFER-UHFFFAOYSA-N

Related Categories

Application

CK-666 may be used to study Arp2/3-mediated structural changes in cells.

Biochem/physiol Actions

CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex and prevents its movement into active conformation.
CK-666 is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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