SML0021

PDI inhibitor 16F16

≥98% (HPLC)

• Synonym(s): 2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid methyl ester, Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate
• Empirical Formula (Hill Notation): C₁₆H₁₇ClN₂O₃
• CAS Number: 922507-80-0
• Molecular Weight: 320.77
• MDL number: MFCD20134198
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825093
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: 12 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: COC(=O)C1(C)N(CCc2c1[nH]c3ccccc23)C(=O)CCl
• InChI: 1S/C16H17ClN2O3/c1-16(15(21)22-2)14-11(7-8-19(16)13(20)9-17)10-5-3-4-6-12(10)18-14/h3-6,18H,7-9H2,1-2H3
• InChI key: BCSIRYFYAKLJDK-UHFFFAOYSA-N

Description

Application

PDI inhibitor 16F16 has been used to inhibit PDI (protein disulfide isomerase) function to examine the functional conservation of PDIs in human embryonic kidney cells.

PDI inhibitor 16F16 may be used in protein disulfide isomerase-mediated cell signaling studies.

Biochem/physiol Actions

16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.

Protein disulfide isomerase (PDI) inhibitor; suppresses apoptosis induced by misfolded proteins

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable