SML0031

DBeQ

≥98% (HPLC)

• Synonym(s): JRF 12, N2,N4-dibenzylquinazoline-2,4-diamine
• Empirical Formula (Hill Notation): C₂₂H₂₀N₄
• CAS Number: 177355-84-9
• Molecular Weight: 340.42
• MDL number: MFCD03691820
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825101
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥20 mg/mL
• storage temp.: room temp
• SMILES string: C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4
• InChI: 1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)
• InChI key: QAIMUUJJAJBPCL-UHFFFAOYSA-N

Description

Application

HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.

Biochem/physiol Actions

ATPase p97 inhibitor.

DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3