SML1414

Liproxstatin-1

>98% (HPLC), powder, ferroptosis inhibitor

• Synonym(s): N-[(3-Chlorophenyl)methyl]-spiro[piperidine-4,2′(1′H)-quinoxalin]-3′-amine, N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4′-piperidine]-2-amine
• Empirical Formula (Hill Notation): C₁₉H₂₁ClN₄
• CAS Number: 950455-15-9
• Molecular Weight: 340.85
• MDL number: MFCD14948691
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825860
• NACRES: NA.77

Properties

• Product Name: Liproxstatin-1, >98% (HPLC)
• Quality Level: 100
• Assay: >98% (HPLC)
• form: powder
• color: white to light brown
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: ClC1=CC(CNC2=NC3=CC=CC=C3NC24CCNCC4)=CC=C1
• InChI: 1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)
• InChI key: YAFQFNOUYXZVPZ-UHFFFAOYSA-N

Description

Application

Liproxstatin-1 has been used as a cell death inhibitor in the cell viability assay and for the determination of lipid peroxidation.

Biochem/physiol Actions

Liproxstatin-1 is a potent inhibitor of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS). Liproxstatin-1 suppressed ferroptosis in human cells and in an ischaemia/reperfusion-induced tissue injury model in mice. Knockout of glutathione peroxidase 4 (Gpx4) Has been shown to cause cell death by ferroptosis. Liproxstatin-1 was able to suppress ferroptosis in Gpx4 knock-out mice.

Liproxstatin-1 is a potent inhibitor of ferroptosis.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable