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Key Documents

SML1620

Sigma-Aldrich

NGI-1

≥95% (HPLC)

Synonym(s):

5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)-benzamide, ML414

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About This Item

Empirical Formula (Hill Notation):
C17H22N4O3S2
CAS Number:
Molecular Weight:
394.51
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(N(C)C)c1cc(c(cc1)N3CCCC3)C(=O)Nc2[s]c(cn2)C

InChI key

QPKGRLIYJGBKJL-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

NGI-1 (ML414) is an inhibitor of Asparagine (N)-linked glycoslysation.
NGI-1 (ML414) is an inhibitor of Asparagine (N)-linked glycoslysation. NGI-1 inhibits the oligosaccharyltransferase, preventing the attachment to the protein. NGI-1 has been shown to induce senescence in receptor tyrosine kinase dependent tumors.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


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