SML2283

Lenalidomide

≥98% (HPLC), powder, cereblon binder

• Synonym(s): Lenalidomide, 1-Oxo-4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole, 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione, 3-(4-Amino-1-oxoisoindolin-2-yl)piperidin-2,6-dione, 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione, CC 5013, CC-5013
• Empirical Formula (Hill Notation): C₁₃H₁₃N₃O₃
• CAS Number: 191732-72-6
• Molecular Weight: 259.26
• MDL number: MFCD07772307
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Product Name: Lenalidomide, ≥98% (HPLC)
• ligand: lenalidomide
• Assay: ≥98% (HPLC)
• form: powder
• reaction suitability: reagent type: ligand
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N
• InChI: 1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
• InChI key: GOTYRUGSSMKFNF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Lenalidomide, a derivative of thalidomide, is an immunomodulatory agent that is approved drug for treatment of multiple myeloma. Apparently Lenalidomide is a ligand of ubiquitin E3 ligase cereblon that induces the enzyme to degrade the Ikaros transcription factors IKAROS family zinc finger 1 (IKZF1) and IKZF3. Lenalidomide possess pleiotropic antitumor effects. It is used in the treatment of 5q-deletion associated myelodysplastic syndrome (del(5q)-MDS).

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H360D,H373
• Precautionary Statements: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B - STOT RE 2
• Target Organs: Blood
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable