SML2896

ONO-2506

≥98% (HPLC)

• Synonym(s): (-)-(2R)-2-Propyloctanoic acid, (2R)-2-Propyloctanoic acid, (R)-(-)-2-Propyloctanoic acid, (R)-2-Propyloctanoic acid, Arundic acid, ONO 2506, ONO2506
• Empirical Formula (Hill Notation): C₁₁H₂₂O₂
• CAS Number: 185517-21-9
• Molecular Weight: 186.29
• MDL number: MFCD08458423
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: oil
• color: colorless to yellow
• storage temp.: −20°C
• SMILES string: OC(=O)[C@@H](CCCCCC)CCC
• InChI: 1S/C11H22O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h10H,3-9H2,1-2H3,(H,12,13)/t10-/m1/s1
• InChI key: YCYMCMYLORLIJX-SNVBAGLBSA-N

Description

Biochem/physiol Actions

Inhibitory astrocytes-modulating agent that exerts glioprotective effects in cultures and in vivo by decreasing intracellular and extracellular S100B levels.

ONO-2506 (arundic acid; (R)-2-propyloctanoic acid) is an inhibitory astrocytes-modulating agent that exerts glioprotective effects against amyloid-β-peptide (Aβ)-induced glial death in astrocyte cultures (50 μM ONO-2506 against 200 μM Aβ25-35, 24 hr; 1321N1 astrocytes) by decreasing both the intracellular and extracellular S100B levels. Blockade of astrocytic activation by ONO-2506 in vivo is shown to offer therapeutic efficacy in animal models of normal tension glaucoma (10 mg/kg po. mice), spinal cord injury (20 mg/kg/d ip or iv rats), brain seizure, ischemic stroke (10 mg/kg/d ip or iv rats), and Parkinson′s disease (30 mg/kg ip mice).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable