SML2908

A71915 trifluoroacetate

≥95% (HPLC)

• Synonym(s): (Arg6, β-cyclohexyl-Ala8, D-Tic16, Arg17, Cys18)-Atrial Natriuretic Factor (6-18) amide (Cys7→Cys18 disulfide), TFA salt, A 71915, A-71915, Arg-Cys-β-cyclohexyl-Ala-Gly-Gly-Arg-Ile-Asp-Arg-Ile-D-Tic-Arg-Cys-NH2 (Cys2→Cys13 disulfide), TFA salt, RC-(Cha)-GGRIDRI-(D-Tic)-RC-NH2 (Cys2→Cys13 disulfide, TFA salt, [Arg6, Cha8]ANP-(6-15)-D-Tic-Arg-Cys-NH2 (Cys7→Cys18 disulfide), TFA salt
• Empirical Formula (Hill Notation): C₆₉H₁₁₆N₂₆O₁₅S₂ · xC₂HF₃O₂
• CAS Number: 132956-87-7
• Molecular Weight: 1613.95 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: powder
• color: white to off-white
• storage temp.: −20°C

Description

Biochem/physiol Actions

A71915 is a potent atrial natriuretic peptide A (ANP, NPPA) receptor (NPR1, ANP-A, ANPR-A, NPR-A) antagonist (pK_i = 9.18 (K_i = 650 nM) by competitive binding against 300 nM rat ANP1-28 to human neuroblastoma NB-OK-1 cells; pA2 = 9.45 against rat ANP-induced cGMP production in NB-OK-1 cells). A71915 is reactive toward dog, human, mouse, rabbit, and rat species, and commonly employed both in cultures (1-10 μM) and in vivo for studying NPR-A-mediated responses.

Atrial natriuretic peptide A (ANP, NPPA) receptor (NPR1, ANPRA, NPRA) antagonist with in vitro and in vivo efficacy.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable