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SML3149

Sigma-Aldrich

BI8626

≥98% (HPLC)

Synonym(s):

BI 8626, BI-8626, N-(3-(Aminomethyl)benzyl)-8-(4-benzylpiperazin-1-yl)pyrimido[5,4-d]pyrimidin-4-amine, N1-[8-[4-(Phenylmethyl)-1-piperazinyl]pyrimido[5,4-d]pyrimidin-4-yl]-1,3-benzenedimethanamine

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About This Item

Empirical Formula (Hill Notation):
C25H28N8
CAS Number:
1875036-75-1
Molecular Weight:
440.54
MDL number:
MFCD32062793
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

Biochem/physiol Actions

BI8626 is a selective HUWE1 (HECTH9; MULE; ARF-BP1) inhibitor (IC50 = 0.9 µM by HUWE1 HECT-domain auto-ubiquitination assay; IC50 >50 µM against other HECT-domain Ub ligases tested). BI8626 inhibits the degradation of HUWE1 target proteiins, including MCL1, MIZ1, and TopBP1 (10-20 µM). BI8626 suppresses Ls174T colony formation (IC50 = 0.7 µM in 5 days) and the growth of three colon carcinoma cell lines (20 µM for 5 days; HCT116, HT29, SW480).
Selective HUWE1 (HECTH9; MULE; ARF-BP1) inhibitor against HUWE1-mediated degration of target proteins.

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application(s)

environmental

application(s)

agriculture

application(s)

environmental

application(s)

environmental

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

300

grade

certified reference material, TraceCERT®

grade

certified reference material, TraceCERT®

grade

certified reference material, TraceCERT®

grade

certified reference material, TraceCERT®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

packaging

ampule of 1 mL

packaging

ampule of 1 mL

packaging

ampule of 1 mL

packaging

ampule of 1 mL

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    R A Tokola et al.
    Cephalalgia : an international journal of headache, 4(4), 253-263 (1984-12-01)
    Tolfenamic acid is a fenamate which inhibits prostaglandin (PG) biosynthesis and may act as a PG antagonist as well. Caffeine and metoclopramide are used in combination with analgesics and ergotamine in the treatment of migraine attacks, but controlled clinical studies
    Don Eslin et al.
    Molecular carcinogenesis, 52(5), 377-386 (2012-01-04)
    Current therapeutic options for recurrent neuroblastoma have poor outcomes that warrant the development of novel therapeutic strategies. Specificity protein (Sp) transcription factors regulate several genes involved in cell proliferation, survival, and angiogenesis. Sp1 regulates genes believed to be important determinants
    Sung Un Kang et al.
    PloS one, 7(4), e34988-e34988 (2012-04-27)
    Nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) is induced by nonsteroidal anti-inflammatory drugs and possesses proapoptotic and antitumorigenic activities. Although tolfenamic acid (TA) induces apoptosis in head and neck cancer cells, the relationship between NAG-1 and TA has not been determined. This
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