SML3610

Gingerenone A

≥95% (HPLC)

• Synonym(s): (4E)​-1,​7-​bis(4-​hydroxy-​3-​methoxyphenyl)​-4-​Hepten-​3-​one, (E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-one
• Empirical Formula (Hill Notation): C₂₁H₂₄O₅
• CAS Number: 128700-97-0
• Molecular Weight: 356.41
• MDL number: MFCD06656136
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Description

Biochem/physiol Actions

Gingerenone A is a potent anticancer agent isolated from Ginger (Zingiber officinale) that exhibits minimal toxicity toward normal cells. Gingerenone A potently inhibits JAK2 (Janus Kinase 2) and S6K1 (p70 ribosomal S6 kinase). Gingerenone A significantly suppressed tumor growth in vivo. Also, it exhibits promising senolytic properties. Gingerenone A selectively eliminate senescent cells in WI-38 human fibroblasts rendered senescent by exposure to ionizing radiation.

JAK2 and S6K1inhibitor; anticancer agent isolated from Ginger; it exhibits promising senolytic properties.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable