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SML3734

Sigma-Aldrich

AO-159

≥98% (HPLC)

Synonym(s):

2,3,6,7-Tetramethyl 9-(4-methoxyphenyl)-1,4,8-trithiaspiro[4.5]deca-2,6,9-triene-2,3,6,7-tetracarboxylate, 9-(4-Methoxyphenyl)-1,4,8-trithiaspiro[4.5]deca-2,6,9-triene-2,3,6,7-tetracarboxylic acid 2,3,6,7-tetramethyl ester

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About This Item

Empirical Formula (Hill Notation):
C22H20O9S3
CAS Number:
Molecular Weight:
524.58
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

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This Item
725226717274B33803
assay

95%

assay

99%

assay

97%

assay

98%

refractive index

n20/D 1.495 (lit.)

refractive index

n20/D 1.486 (lit.)

refractive index

-

refractive index

n20/D 1.470 (lit.)

bp

81-82 °C/10 mmHg (lit.)

bp

225 °C (lit.)

bp

-

bp

89 °C (lit.)

density

1.067 g/mL at 20 °C (lit.)

density

0.981 g/mL at 25 °C (lit.)

density

-

density

0.906 g/mL at 25 °C (lit.)

Biochem/physiol Actions

AO-159 is a cell penetrant and potent pan-HMT (pan- Histone Methyltransferase) inhibitor that effectively inhibit the enzymatic activity of both G9a and Suv39H1 enzymes. AO-159 potently reduces the levels of H3K9me1, H3K9me2, and H3K9me3 in COS7 cells. In inhibits the five histone H3K9 methylating enzymes Suv39H1, Suv39H2, SETDB1, G9a, and GLP at low micromolar concentrations.
Cell penetrant and potent pan-HMT (pan- Histone Methyltransferase) inhibitor that effectively inhibit the enzymatic activity of both G9a and Suv39H1 enzymes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Franziska Curdt et al.
Optics express, 23(24), 30891-30903 (2015-12-25)
Despite the need for isotropic optical resolution in a growing number of applications, the majority of super-resolution fluorescence microscopy setups still do not attain an axial resolution comparable to that in the lateral dimensions. Three-dimensional (3D) nanoscopy implementations that employ
Erdinc Sezgin et al.
Journal of lipid research, 57(2), 299-309 (2015-12-25)
Cholesterol (Chol) is a crucial component of cellular membranes, but knowledge of its intracellular dynamics is scarce. Thus, it is of utmost interest to develop tools for visualization of Chol organization and dynamics in cells and tissues. For this purpose
Daniel Neumann et al.
PMC biophysics, 3(1), 4-4 (2010-03-09)
The voltage-dependent anion channel (VDAC, also known as mitochondrial porin) is the major transport channel mediating the transport of metabolites, including ATP, across the mitochondrial outer membrane. Biochemical data demonstrate the binding of the cytosolic protein hexokinase-I to VDAC, facilitating
Christian Kukat et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(33), 13534-13539 (2011-08-03)
Mammalian mtDNA is packaged in DNA-protein complexes denoted mitochondrial nucleoids. The organization of the nucleoid is a very fundamental question in mitochondrial biology and will determine tissue segregation and transmission of mtDNA. We have used a combination of stimulated emission
Roman Schmidt et al.
Nano letters, 9(6), 2508-2510 (2009-05-23)
Because of the diffraction resolution barrier, optical microscopes have so far failed in visualizing the mitochondrial cristae, that is, the folds of the inner membrane of this 200 to 400 nm diameter sized tubular organelle. Realizing a approximately 30 nm

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