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SRP6006

Sigma-Aldrich

IL-1RA murine

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

Synonym(s):

ICIL-1RA, IL-1ra3, IL1 inhibitor, IL1F3, IRAP

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5 MG
CA$862.00
10 MG
CA$1,590.00

About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

CA$862.00


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biological source

mouse

recombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE)

form

lyophilized

mol wt

17.4 kDa

packaging

pkg of 50 μg

technique(s)

activity assay: suitable

impurities

Endotoxin, tested

NCBI accession no.

UniProt accession no.

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This Item
483176235865751162
assay

98%

assay

95%

assay

99%

assay

97%

density

0.89 g/mL at 25 °C (lit.)

density

0.89 g/mL at 25 °C (lit.)

density

0.894 g/mL at 25 °C (lit.)

density

0.898 g/mL at 25 °C

contains

500 ppm BHT as inhibitor

contains

-

contains

monomethyl ether hydroquinone as inhibitor

contains

~200 ppm MEHQ

form

liquid

form

-

form

liquid

form

liquid

refractive index

n20/D 1.415 (lit.)

refractive index

n20/D 1.506 (lit.)

refractive index

n20/D 1.423 (lit.)

refractive index

n20/D 1.419

bp

51-51.5 °C/20 mmHg (lit.)

bp

140-143 °C/751 mmHg (lit.)

bp

162-165 °C (lit.)

bp

-

General description

Research area: IMMUNO AND CKS

Interleukin-1 receptor antagonist (IL-1 RA) is a member of the interleukin 1 cytokine family. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.[1] IL-1RA mouse recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2.
Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL1 ra Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques.

Application

IL-1RA murine has been used as an antagonist to the interleukin-1 receptor in fibroblasts.[2]

Biochem/physiol Actions

Interleukin-1 receptor antagonist (IL-1Ra) protein mediates the inhibition of interleukin 1-α (IL1A) and interleukin 1-β (IL1B) activities. It is also involved in the modulation of IL-1 related immune and inflammatory responses.[1] A polymorphism in the IL-1Ra gene is reported to be associated with an increased risk of osteoporotic fractures[3] and gastric cancer.[4] IL-1Ra is effective in treating bronchopulmonary dysplasia in murine models.[5]This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B) and modulates a variety of interleukin 1 related immune and inflammatory responses.

Physical form

Lyophilized from H?O containing NaHCO?

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile ddH?O to a concentration ? 100 μg/ml. This solution can then be diluted into other aqueous buffers.

Other Notes

The IL1RA is purified by proprietary chromatographic techniques.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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