T4382
apo-Transferrin human
powder, ≥98% (agarose gel electrophoresis)
Synonym(s):
Human transferrin, Siderophilin
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About This Item
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biological source
human
Quality Level
Assay
≥98% (agarose gel electrophoresis)
form
powder
mol wt
76-81 kDa
Iron content
≤0.005%
technique(s)
cell culture | mammalian: suitable
impurities
HIV and HBsAg, source material tested negative
solubility
H2O: 50 mg/mL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... TF(7018)
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General description
Apo-transferrin human is a glycoprotein, possessing homologous carboxyl and amino domain. Both the domain binds to one molecule of iron. Only 30% of transferrin is saturated with iron in the amino domain. Apo-transferrin in human is encoded by the gene TF which is localized on human chromosome 3q22.1.
Application
Apo-Transferrin human has been used:
- to determine the competitive binding of bismuth to albumin and transferrin by fast performance liquid chromatography (FPLC)
- to study titanium-transferrin complex by electrochemical method
- in the preparation of transferrin solution and in the formation of conjugates with ruthenium-complexes for cellular viability studies
Biochem/physiol Actions
Apo-transferrin is an iron transport protein. The concentration of transferrin in blood plasma is about 35 μM. Transferrin also functions in the transport of therapeutic, diagnostic and toxic ions like Ga3+, Ru3+ and Al3+. Polymorphism in TF gene has pathological implications in Parkinson′s disease.
Apo-transferrin is required for the survival and differentiation of oligodendroglial cells.
Other Notes
Non-heme iron-transport protein.
Linkage
Similar to T 2252
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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