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Key Documents

T7040

Sigma-Aldrich

Tyrphostin 1

≥98%

Synonym(s):

(4-Methoxybenzylidene)malononitrile

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About This Item

Linear Formula:
CH3OC6H4CH=C(CN)2
CAS Number:
Molecular Weight:
184.19
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98%

form

solid

potency

>1250 μM IC50 (negative control)

mp

113-116 °C (lit.)

solubility

chloroform: soluble 50 mg/mL, clear, light yellow
DMSO: soluble

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)\C=C(/C#N)C#N

InChI

1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3

InChI key

UOHFCPXBKJPCAD-UHFFFAOYSA-N

Gene Information

human ... EGFR(1956)

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Application

Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells.

Biochem/physiol Actions

EGFR tyrosine kinase inhibitor.
Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation,. Furthermore, studies have reported that tyrphostin 1 can block Ca2+ channels and inhibit growth in vascular smooth muscle cells,.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

Tyrphostin 1 dissolves in chloroform at 50 mg/ml to yield a clear, light yellow solution. It is also soluble in DMSO.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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