UC148

6-Hydroxychlorzoxazone

≥98% (HPLC), solid, chlorzoxazone metabolite

• Synonym(s): 5-Chloro-6-hydroxy-2(3H)-benzoxazolone, 5-Chloro-6-hydroxybenzoxazone
• Empirical Formula (Hill Notation): C₇H₄ClNO₃
• CAS Number: 1750-45-4
• Molecular Weight: 185.56
• MDL number: MFCD00143502
• UNSPSC Code: 12161501
• PubChem Substance ID: 24724641
• NACRES: NA.77

Properties

• Product Name: 6-Hydroxychlorzoxazone, ≥98% (HPLC)
• Quality Level: 200
• Assay: ≥98% (HPLC)
• form: solid
• color: white to pink
• solubility: methanol: soluble
• storage temp.: 2-8°C
• SMILES string: Oc1cc2OC(=O)Nc2cc1Cl
• InChI: 1S/C7H4ClNO3/c8-3-1-4-6(2-5(3)10)12-7(11)9-4/h1-2,10H,(H,9,11)
• InChI key: AGLXDWOTVQZHIQ-UHFFFAOYSA-N

Description

Application

6-Hydroxychlorzoxazone has been used for HPLC-based metabolic assays of chlorzoxazone.

6-hydroxy Chlorzoxazone has been used: as a reference standard to monitor substrate depletion or 6-hydroxy chlorzoxazone formation by cytochrome P450 family 2 subfamily E member 1 (CYP2E1)in recombinant human enzyme screening. 6-Hydroxychlorzoxazone has been used for high-performance liquid chromatography (HPLC)-based metabolic assays of chlorzoxazone.

CYP2E1 & 1A2 metabolite of chlorzoxazone.

Biochem/physiol Actions

6-hydroxy Chlorzoxazone is a novel metabolite of chlorzoxazone. It is formed by the hydroxylation of chlorzoxazone by cytochrome P450 family 2 subfamily E member 1 (CYP2E1) enzyme. The determination of formation and clearance of 6-hydroxychlorzoxazone is used as a reliable marker of CYP2E1 metabolic activity.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

6-Hydroxychlorzoxazone is soluble in methanol.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves