440191

Hexamethyldisilazane

reagent grade, ≥99%

• Sinonimo/i: Bis(trimethylsilyl)amine, HMDS
• Formula condensata: (CH₃)₃SiNHSi(CH₃)₃
• CAS Number: 999-97-3
• Peso molecolare: 161.39
• Beilstein: 635752
• Numero CE: 213-668-5
• Numero MDL: MFCD00008259
• Codice UNSPSC: 12352103
• ID PubChem: 24867576
• NACRES: NA.23

Proprietà

• Grado: reagent grade
• Livello qualitativo: 300
• Saggio: ≥99%
• Stato: liquid
• Indice di rifrazione: n20/D 1.407 (lit.)
• P. ebollizione: 125 °C (lit.)
• Stringa SMILE: C[Si](C)(C)N[Si](C)(C)C
• InChI: 1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3; FFUAGWLWBBFQJT-UHFFFAOYSA-N

Descrizione

Descrizione generale

Hexamethyldisilane (HMDS) is a stable and effectivereagent for trimethylsilylation of hydrogen-labile substrates such as alcohols,amines, and carboxylic acids. It is commonly used for the protection of sensitivefunctional groups during chemical synthesis. Owing to its low cost, high vapor pressure, and safety, itis widely used as a precursor in chemical vapor deposition(CVD) reactions.

Applicazioni

Hexamethyldisilane (HMDS) can be used:

• As a silylating agent in the trimethylsilylation of alcohols under nearly neutral reaction conditions.
• To control the molecular weights of polypeptides during ring-opening polymerization of α-amino acid N-carboxyanhydrides.
• To fabricate silicon carbonitride thin films by plasma-enhanced CVD.
• For specimen preparation for scanning electron microscopy and the preparation of trimethylsilyl ethers from hydroxy compounds.

Caratteristiche e vantaggi

• High chemicalstability and low molecular weight
• Nontoxic andcost-effective reagent
• Ammonia is theonly byproduct generated during silylation
• Silylationreaction using HDMS is nearly neutral and does not need any precaution

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H302 + H332,H311,H412
• Consigli di prudenza: P210 - P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): 52.5 °F - closed cup
• Punto d’infiammabilità (°C): 11.4 °C - closed cup
• Dispositivi di protezione individuale: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter