14606

Colesterolo

tested according to Ph. Eur.

• Sinonimo/i: 3β-idrossi-5-colestene, 5-colestene-3β-olo
• Formula empirica (notazione di Hill): C₂₇H₄₆O
• CAS Number: 57-88-5
• Peso molecolare: 386.65
• Beilstein: 1915888
• Numero CE: 200-353-2
• Numero MDL: MFCD00003646
• Codice UNSPSC: 41141804
• ID PubChem: 329750548
• NACRES: NA.21

Proprietà

• agenzia: USP/NF; tested according to Ph. Eur.
• Livello qualitativo: 100
• Stato: powder
• P. ebollizione: 360 °C (lit.)
• Punto di fusione: 147-149 °C (lit.)
• Solubilità: chloroform: soluble 1 gm in 4.5 ml; diethyl ether: soluble 1 gm in 2.8 ml; pyridine: soluble 1 gm in 1.5 ml; H₂O: insoluble; acetone: soluble; alcohol: slightly soluble; alcohol: very soluble (Hot); benzene: soluble; dioxane: soluble; ethyl acetate: soluble; hexane: soluble; oil: soluble; petroleum ether: soluble
• Densità: 1.067 g/mL at 25 °C (lit.)
• applicazioni: pharmaceutical (small molecule)
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1; HVYWMOMLDIMFJA-DPAQBDIFSA-N
• Informazioni sul gene: human ... POLA1(5422), TOP2A(7153) ; rat ... Ar(24208), Polb(29240)

Descrizione

Applicazioni

Cholesterol was used for preparing ISCOMS containing ovalbumin (OVA) for studying whether the incorporation of the protein antigen ovalbumin (OVA) in lipophilic immune-stimulating complexes (ISCOMS) induces very strong primary immune responses. It was incorporated in animal feed to study the effect of cholesterol-rich diet.

Azioni biochim/fisiol

Componente principale di tutte le membrane biologiche; il colesterolo rappresenta il 25% circa dei lipidi cerebrali totali.

Cholesterol is a lipid that makes up about 20-25% of the structural components of the cell membranes. It determines the fluidity and permeability of the membrane, making it permeable to water but not to ions and protons. Cholesterol also regulates the functions of the transporters and signaling proteins present on the plasma membrane. The major sites of cholesterol synthesis are small intestine and liver.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)