T2376

L-Thyroxine

≥98% (HPLC)

• Sinonimo/i: 3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T₄
• Formula condensata: HOC₆H₂(I)₂OC₆H₂(I)₂CH₂CH(NH₂)CO₂H
• CAS Number: 51-48-9
• Peso molecolare: 776.87
• Beilstein: 2228515
• Numero CE: 200-101-1
• Numero MDL: MFCD00002595
• Codice UNSPSC: 51111800
• ID PubChem: 24900033
• NACRES: NA.32

Proprietà

• Origine biologica: synthetic
• Livello qualitativo: 200
• Sterilità: non-sterile
• Saggio: ≥98% (HPLC)
• Stato: powder
• tecniche: cell culture | mammalian: suitable
• Punto di fusione: 223 °C (dec.) (lit.)
• Solubilità: 4 M NH₄OH in methanol: 50 mg/mL, clear to hazy, yellow
• Condizioni di spedizione: ambient
• Temperatura di conservazione: room temp
• Stringa SMILE: N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
• InChI: 1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1; XUIIKFGFIJCVMT-LBPRGKRZSA-N
• Informazioni sul gene: human ... THRA(7067), THRB(7068), TTR(7276) ; mouse ... Cnr2(12802) ; rat ... Cnr1(25248)

Descrizione

Applicazioni

L-Thyroxine was used to study the light-induced hormone conversion of T4 to T3 in regulation of photoperiodic response of gonads in Japanese quail. The product was used as a test compound for studying the impact of numerous hormones on the surface morphology of rat testicular cells in culture.

Azioni biochim/fisiol

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

L-Thyroxine is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells. L-Thyroxine reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints. Hence, facilitates in improving cardiovascular risk factor as well as can enhance symptoms of tiredness.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Nota sulla preparazione

L-Thyroxine dissolves in 4M ammonium hydroxide in Methanol at 50 mg/ml to yield a clear to hazy yellow to dark yellow solution.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H372
• Consigli di prudenza: P260 - P264 - P270 - P314 - P501
• Classi di pericolo: STOT RE 1
• Organi bersaglio: Thyroid,Cardio-vascular system,Kidney
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)