215163

Chloroacetic anhydride

95%

• Synonym(s): Monochloroacetic acid anhydride
• Linear Formula: (ClCH₂CO)₂O
• CAS Number: 541-88-8
• Molecular Weight: 170.98
• Beilstein: 774533
• EC Number: 208-794-2
• MDL number: MFCD00000929
• UNSPSC Code: 12352100
• PubChem Substance ID: 24852874
• NACRES: NA.22

Properties

• vapor pressure: <0.75 mmHg ( 20 °C)
• Quality Level: 200
• Assay: 95%
• form: solid
• bp: 120-123 °C/20 mmHg (lit.)
• mp: 48-60 °C (lit.)
• solubility: chloroform: soluble 100 mg/mL, clear, colorless to faintly yellow
• functional group: anhydride; chloro; ester
• SMILES string: ClCC(=O)OC(=O)CCl
• InChI: 1S/C4H4Cl2O3/c5-1-3(7)9-4(8)2-6/h1-2H2
• InChI key: PNVPNXKRAUBJGW-UHFFFAOYSA-N

Description

Application

Chloroacetic anhydride has been used in the synthesis of:

• 3,3′-bis(sulfonato)-4,4′-bis(chloroacetamido)azobenzene (BSBCA), a water-soluble, thiol-reactive and photo-switchable cross-linker
• D,L-7-azatryptophan (D,L-7AW)
• 2-methyl-[3,4-di-O-acetyl-6-O-(chloroacetyl)-1,2-dideoxy-α-D-glucopyrano]-[2′,1′:4,5]-2-oxazoline

Safety Information

• Pictograms: GHS06,GHS05
• Signal Word: Danger
• Hazard Statements: H301,H314
• Precautionary Statements: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1B
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): 289.4 °F - closed cup
• Flash Point(C): 143 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves