498181

2-Chloro-5-iodopyridine

97%

• Empirical Formula (Hill Notation): C₅H₃ClIN
• CAS Number: 69045-79-0
• Molecular Weight: 239.44
• MDL number: MFCD01863635
• UNSPSC Code: 12352100
• PubChem Substance ID: 24873177
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 97%
• mp: 95-98 °C (lit.)
• functional group: chloro; iodo
• SMILES string: Clc1ccc(I)cn1
• InChI: 1S/C5H3ClIN/c6-5-2-1-4(7)3-8-5/h1-3H
• InChI key: QWLGCWXSNYKKDO-UHFFFAOYSA-N

Description

General description

2-Chloro-5-iodopyridine is a halo-substituted pyridine.

Application

2-Chloro-5-iodopyridine may be used as a reagent in the multi-step synthesis of (±)-epibatidine.
It may be used in the synthesis of:

• 2-Chloro-5-phenylpyridine via Suzuki coupling reaction with phenylboronic acid dimethyl ester.
• Exo-5- and exo-6- (6′-chloro-3′-pyridyl)-2-azabicyclo[2.2.1]heptanes via Heck coupling reaction with N-protected 2-azabicyclo[2.2.1]hept-5-enes.
• Substituted diaryliodonium salts.
• 3-Exo-5′-(2′-Chloropyridinyl)-8-(ethoxycarbonyl)-8-azabicyclo[3.2.1]octane.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves