700016P

cholesterol sulfate

Avanti Research^™ - A Croda Brand 700016P

• Synonym(s): cholesterol sulfonate; cholesteryl sulfate; sodium cholesteryl sulfate; cholesteryl sulphate
• Empirical Formula (Hill Notation): C₂₇H₄₅NaO₄S
• CAS Number: 2864-50-8
• Molecular Weight: 488.70
• MDL number: MFCD00079091
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• description: cholesterol 3-sulfate (sodium salt)
• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 g (700016P-1g); pkg of 1 × 25 mg (700016P-25mg); pkg of 1 × 500 mg (700016P-500mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 700016P
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [Na+].[S](=O)(=O)([O-])O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CCCC(C)C)C)(CC3)C)CC=C2C1)C
• InChI: 1S/C27H46O4S.Na/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(31-32(28,29)30)13-15-26(20,4)25(22)14-16-27(23,24)5;/h9,18-19,21-25H,6-8,10-17H2,1-5H3,(H,28,29,30);/q;+1/p-1/t19-,21+,22+,23-,24+,25+,26+,27-;/m1./s1
• InChI key: LMPVQXVJTZWENW-KPNWGBFJSA-M

Description

General description

Cholesterol sulfate is synthesized by the sulfoconjugation of cholesterol in the presence of enzyme cholesterol sulfotransferase. It is present in brain, lungs, hair and skin tissues as well as cells including erythrocytes, platelets and spermatozoa.

Application

Cholesterol sulfate has been used in micelle preparation and in surface plasmon resonance (SPR) studies.

Biochem/physiol Actions

Cholesterol sulfate is associated with atherosclerotic lesions and serves as a substrate for platelet adhesion. It stabilizes the spermatozoa membranes and erythrocytes. Cholesterol sulfate is involved in the keratinocyte differentiation and its levels are elevated in recessive X-linked ichthyosis. It serves as a ligand for retinoic acid-related orphan receptor α (RORα). Cholesterol sulfate regulates glucose metabolism and is a potential target for metabolic disorders. It is also a potential marker for human uterine cervical carcinoma tissue and prostate carcinoma.

Packaging

20 mL Clear Glass Screw Cap Vial (700016P-1g)

20 mL Clear Glass Screw Cap Vial (700016P-500mg)

5 mL Amber Glass Screw Cap Vial (700016P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable