142387

2,4,6-Trimethylpyridine

ReagentPlus^®, 99%

• Synonym(s): 2,4,6-Collidine, sym-Collidine
• Empirical Formula (Hill Notation): C₈H₁₁N
• CAS Number: 108-75-8
• Molecular Weight: 121.18
• Beilstein: 107283
• EC Number: 203-613-3
• MDL number: MFCD00006338
• UNSPSC Code: 12352100
• PubChem Substance ID: 57647138
• NACRES: NA.21

Properties

• Quality Level: 200
• product line: ReagentPlus^®
• Assay: 99%
• form: liquid
• refractive index: n20/D 1.498 (lit.)
• bp: 171-172 °C (lit.)
• mp: −43 °C (lit.)
• density: 0.917 g/mL at 25 °C (lit.)
• SMILES string: Cc1cc(C)nc(C)c1
• InChI: 1S/C8H11N/c1-6-4-7(2)9-8(3)5-6/h4-5H,1-3H3
• InChI key: BWZVCCNYKMEVEX-UHFFFAOYSA-N

Description

General description

2,4,6-Trimethylpyridine is a pyridine derivative. It has a pK of 7.4. The product can react with trifluoroiodomethane in cyclopentane solution to afford 1:1 complex. This complex was investigated by NMR (Nuclear Magnetic Resonance) spectroscopy. Collidine-buffered osmium tetroxide solutions have been prepared by adding osmium tetroxide solution to it. These solutions have been used as fixative for electron microscopic studies.
2,4,6-Trimethylpyridine can undergo oxidation with potassium permanganate to form 2,4,6-pyridinetricarboxylic acid.

Hindered base.

Application

2,4,6-Trimethylpyridine (collidine, s-collidine, 2,4,6-collidine) has been used in the preparation of a library of N-acyl aminocoumarins bearing low-molecular-weight N-acyl groups.

Tissue fixative for electron microscopy.

Useful solvent for the cleavage of hindered esters by anhydrous lithium iodide.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06
• Signal Word: Danger
• Hazard Statements: H226,H302,H311,H315,H319,H335,H412
• Precautionary Statements: P210 - P273 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 131.0 °F - closed cup
• Flash Point(C): 55 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves