G8919

Anti-Growth Hormone Receptor antibody produced in goat

affinity isolated antibody, lyophilized powder

• Synonym(s): Anti-GHR
• MDL number: MFCD06201935
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: goat
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: mouse
• technique(s): immunohistochemistry: 5-15 μg/mL using cells and tissues; western blot: 0.1-0.2 μg/mL
• UniProt accession no.: P16882
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: mouse ... Ghr(14600)

Description

General description

By immunoblotting, this antibody shows ~50% cross-reactivity with recombinant rat GHR and 20% cross-reactivty with recombinant human GHR.

Growth Hormone Receptor encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of intra- and intercellular signal transduction pathways.

Immunogen

purified, NSO-derived, recombinant mouse growth hormone receptor extracellular domain.

Application

Anti-Growth Hormone Receptor antibody produced in goat was used to study the protein and protein phosphorylation levels in rat primary hippocampal cultures using Li-cor Odyssey fluorescence technology.

Biochem/physiol Actions

Growth hormone (GH) is secreted by the anterior pituitary and functions by binding specific growth hormone receptor (GHR). GH stimulates the secretion of insulin-like growth factor-1 that mediates some of its growth promoting actions. The activity of GH/GHR is important for normal physiology and aging processes.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves