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G9048

Sigma-Aldrich

GANT61

≥98% (HPLC)

Synonym(s):

2,2′-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl-benzenamine, NSC 136476

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100 μL
₩8,04,185

About This Item

Empirical Formula (Hill Notation):
C27H35N5
CAS Number:
500579-04-4
Molecular Weight:
429.60
MDL number:
MFCD14635408
UNSPSC Code:
51111800
NACRES:
NA.77

₩8,04,185

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >2 mg/mL

storage temp.

2-8°C

SMILES string

N2(C(N(CCC2)Cc4c(cccc4)N(C)C)c3ccncc3)Cc1c(cccc1)N(C)C

InChI

1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3

InChI key

KVQOGDQTWWCZFX-UHFFFAOYSA-N

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Show Differences

1 of 4

This Item
JKA4105438901776262
1-{4-[1,2-Diphenyl-2-(p-tolyl)vinyl]phenyl}-1H-pyrrole-2,5-dione

797316

1-{4-[1,2-Diphenyl-2-(p-tolyl)vinyl]phenyl}-1H-pyrrole-2,5-dione

HS-PEG1500-SH average Mn 1,500

JKA4105

HS-PEG1500-SH

5-(4-Pyridyl)-1H-1,2,4-triazole-3-thiol 98%

438901

5-(4-Pyridyl)-1H-1,2,4-triazole-3-thiol

3,6-Bis(5-bromo-2-thienyl)-2,5-bis(2-hexyldecyl)-2,5-dihydro-pyrrolo[3,4-c]pyrrole-1,4-dione 98%

776262

3,6-Bis(5-bromo-2-thienyl)-2,5-bis(2-hexyldecyl)-2,5-dihydro-pyrrolo[3,4-c]pyrrole-1,4-dione

assay

98%

assay

-

assay

98%

assay

98%

form

solid

form

liquid

form

powder

form

solid

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

Biochem/physiol Actions

GANT61 blocks hedgehog pathway signaling by inhibiting the transcripional activity of Gli1 (IC50 = 5 μM). GANT 61 led to a regression of 22Rv1 human prostate tumor cell xenografts in nude mice.
GANT61 is a Hh pathway Gli Inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    026M4716V
    035M4728V
    024M4711V
    053M4724V
    011M4625V

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