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H4538

Sigma-Aldrich

Anti-Histone Deacetylase 5 (HDAC5) antibody, Mouse monoclonal

clone HDAC5-35, purified from hybridoma cell culture

Synonym(s):

Anti-HD5

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40 MG
CA$681.00

CA$681.00

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40 MG
CA$681.00

About This Item

MDL number:
MFCD04040361
UNSPSC Code:
12352203
NACRES:
NA.41

CA$681.00

Please contact Customer Service for Availability
Request a Bulk Order
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biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

HDAC5-35, monoclonal

form

buffered aqueous solution

mol wt

antigen ~124 kDa

species reactivity

rat, mouse, human

concentration

~2 mg/mL

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grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

application(s)

pharmaceutical

application(s)

pharmaceutical

application(s)

pharmaceutical

application(s)

pharmaceutical small molecule

agency

traceable to USP 1592781

agency

traceable to USP 1592737

agency

traceable to USP 1031478

agency

traceable to USP 1042690

API family

quetiapine

API family

quetiapine

API family

-

API family

aripiprazole

CofA

current certificate can be downloaded

CofA

current certificate can be downloaded

CofA

current certificate can be downloaded

CofA

current certificate can be downloaded

packaging

pkg of 40 mg

packaging

pkg of 40 mg

packaging

pkg of 100 mg

packaging

pkg of 100 mg

General description

Monoclonal Anti-Histone Deacetylase 5 (HDAC5) (mouse IgG1 isotype) is derived from the HDAC5-35 hybridoma produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice immunized with a synthetic peptide. Mammalian HDACs can be divided into three classes according to sequence homology. Class II consists of the yeast Hda1-like proteins HDAC4, HDAC5, HDAC6, HDAC7, HDAC9 and HDAC10. Histone deacetylase 5 (HDAC5) is a histone deacetylase, located on human chromosome 17q21.

Application

Anti-Histone Deacetylase 5 (HDAC5) antibody, Mouse monoclonal has been used in:
  • western blotting
  • immunostaining
  • enzyme-linked immunosorbent assay (ELISA)
  • immunocytochemistry
  • immunoprecipitation

Biochem/physiol Actions

Histone deacetylase 5 (HDAC5) promotes progression of the cell cycle, cell proliferation and apoptosis. HDAC5 activity is important for the differentiation of muscle cells by binding, through its N-terminal domain, to the myocyte enhancer factor-2 (Mef2) protein, thus repressing expression of MEF2 downstream genes. Overexpression of HDAC5 in different cancer cells suppresses their growth by induction of apoptosis in a p53-independent manner. Reduced expression of the protein is observed in colon cancer and acute myeloid leukemia.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

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    Certificates of Analysis (COA)

    Lot/Batch Number
    088M4826
    22171128
    064K4783

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