S4317

SB 431542 hydrate

≥98% (HPLC), powder, inhibits activation of SMAD proteins

• Synonym(s): 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate
• Empirical Formula (Hill Notation): C₂₂H₁₆N₄O₃ · xH₂O
• CAS Number: 301836-41-9
• Molecular Weight: 384.39 (anhydrous basis)
• MDL number: MFCD11045982
• UNSPSC Code: 51111800
• PubChem Substance ID: 24724609
• NACRES: NA.77

Properties

• Product Name: SB 431542 hydrate, ≥98% (HPLC), powder
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: soluble 10 mg/mL; H₂O: insoluble
• originator: GlaxoSmithKline
• storage temp.: −20°C
• SMILES string: O.NC(=O)c1ccc(cc1)-c2nc(-c3ccc4OCOc4c3)c([nH]2)-c5ccccn5
• InChI: 1S/C22H16N4O3.H2O/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17;/h1-11H,12H2,(H2,23,27)(H,25,26);1H2
• InChI key: WQUIJVKNPYBZOF-UHFFFAOYSA-N

Description

Application

SB-431542 was used to study the correlation of platelet-derived growth factor receptor B expression and TGF-β pathway activation in colorectal tumor cells. It was used to study the role of TGF-β signaling in modulation of extracellular matrix and myoblast differentiation.

Biochem/physiol Actions

Potent and selective inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors.

SB-431542 inhibits the TGF-β-mediated activation of SMAD proteins, expression of collagen and fibronectin, cell proliferation and cell motility. It does not inhibit kinases that are activated in response to serum or stress such as ERK, p38 or JNK.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves