SAB6010054

Anti-phospho-PAK1/PAK2/PAK3 (S144+S141+S139) antibody, clone 3H12, Rabbit Monoclonal

recombinant, expressed in HEK293F cells

• Synonym(s): Serine/threonine-protein kinase PAK 3, Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-3, PAK3, OPHN3
• UNSPSC Code: 12352203

Properties

• recombinant: expressed in HEK 293 F cells
• Quality Level: 100
• conjugate: unconjugated
• antibody product type: primary antibodies
• clone: 3H12, recombinant monoclonal
• form: liquid
• mol wt: 150 kDa
• purified by: affinity chromatography
• species reactivity: human
• concentration: 0.53mg/ml
• technique(s): ELISA: 2000:10000; flow cytometry: 1:50-1:200; immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200
• isotype: IgG
• UniProt accession no.: O75914/Q13153/Q13177
• shipped in: wet ice
• storage temp.: -10 to -25°C
• target post-translational modification: phosphorylation (pSer144+pSer141+pSer139)

Description

General description

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.

Immunogen

A synthesized peptide derived from human Phospho-PAK1/PAK2/PAK3 (S144+S141+S139)

Sequence

YM-pS-FT

Physical form

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage and Stability

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable