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SML3565

Sigma-Aldrich

AT1

≥98% (HPLC)

Synonym(s):

(2S,4R)-1-(2R)-2-Acetamido-3-[[6-[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamido]hexyl]thio]-3-methylbutanoyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl)pyrrolidinine-2-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C48H58ClN9O5S3
CAS Number:
2098836-45-2
Molecular Weight:
972.68
MDL number:
MFCD31656710
UNSPSC Code:
12352200

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

AT1 is a cell penetrant Proteolysis Targeting Chimera (PROTAC) that selectively targets BET4 proteins for degradation by recruitments of ubiquitin E3 ligase. AT1 comprise (+)-JQ1 as a BET4 binding domain and E3 ligase specific VHL (von Hippel-Lindau) ligand connected through a linker.
PROTAC containing (+)-JQ1 that selectively binds to BRD4

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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