SML3659

SJB2-043

≥98% (HPLC)

• Synonym(s): 2-Phenyl-naphth[2,3-d]oxazole-4,9-dione
• Empirical Formula (Hill Notation): C₁₇H₉NO₃
• CAS Number: 63388-44-3
• Molecular Weight: 275.26
• MDL number: MFCD26960957
• UNSPSC Code: 12352200
• NACRES: NA.25

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: , Faint green to yellow
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: 2-8°C
• SMILES string: n1c2c([o]c1c4ccccc4)C(=O)c3c(cccc3)C2=O
• InChI: 1S/C17H9NO3/c19-14-11-8-4-5-9-12(11)15(20)16-13(14)18-17(21-16)10-6-2-1-3-7-10/h1-9H
• InChI key: CMYQQADDUUDCCA-UHFFFAOYSA-N

Description

Biochem/physiol Actions

SJB2-043 is a ubiquitin-specific protease USP1 inhibitor (IC50 = 544 nM using USP1/UAF1 complex) that exhibits anti-proliferation efficacy against chronic and acute myeloid leukemia lines (IC50 <2 µM; K562, OCI-AML3, SK-NO1, U937) and primary acute myelogenous leukemia (AML) patient-derived leukemic cells by promoting the degradation of transcription factor DNA binding 1 (ID1). SJB2-043 is also reported to be an allosteric site-targeting inhibitor against PLPro (IC50 = 0.56 μM), the papain-like cysteine protease with deubiquitination and deISGylation activities that suppress host innate immune responses toward SARS-CoV-2 infection.

Ubiquitin-specific protease USP1 inhibitor with anti-leukemia efficacy. Also reported to inhibit SARS-CoV-2 papain-like cysteine protease PLPro.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable