T122

Telenzepine dihydrochloride hydrate

solid, ≥98% (HPLC)

• Synonym(s): 4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrochloride
• Empirical Formula (Hill Notation): C₁₉H₂₂N₄O₂S · 2HCl · xH₂O
• CAS Number: 147416-96-4
• Molecular Weight: 443.39 (anhydrous basis)
• MDL number: MFCD11045947
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277875
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: H₂O: >10 mg/mL
• SMILES string: O.Cl.Cl.CN1CCN(CC1)CC(=O)N2c3ccccc3NC(=O)c4csc(C)c24
• InChI: 1S/C19H22N4O2S.2ClH.H2O/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22;;;/h3-6,12H,7-11H2,1-2H3,(H,20,25);2*1H;1H2
• InChI key: HZWCRPGARSMPNS-UHFFFAOYSA-N
• Gene Information: human ... CHRM1(1128)

Description

Application

Telenzepine dihydrochloride hydrate was used to study M₁ muscarinic receptor-mediated signaling in juvenile rat hippocampus and rat urinary bladder.

Biochem/physiol Actions

Telenzepine is an analog of pirenzepine and inhibits the secretion of gastric acid. It is an antagonist to M₁-receptor and targets the oxyntic gastric glands and the salivary glands.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves