240931

Saccharin

≥99%

• 동의어(들): 2,3-Dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide, 2-Sulfobenzoic acid imide, o-Benzoic sulfimide
• 실험식(Hill 표기법): C₇H₅NO₃S
• CAS Number: 81-07-2
• Molecular Weight: 183.18
• Beilstein: 6888
• EC Number: 201-321-0
• MDL number: MFCD00005866
• UNSPSC 코드: 12352100
• PubChem Substance ID: 24854444
• NACRES: NA.22

속성

• Quality Level: 200
• 분석: ≥99%
• 양식: powder
• mp: 226-229 °C (lit.)
• solubility: acetone: 1g in 12mL(lit.); alcohol: 1g in 31mL(lit.); boiling water: 1g in 25mL(lit.); water: 1g in 25mL(lit.)
• SMILES string: O=C1NS(=O)(=O)c2ccccc12
• InChI: 1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
• InChI key: CVHZOJJKTDOEJC-UHFFFAOYSA-N

설명

일반 설명

The biodegradation of saccharin (2-sulfobenzoic acid imide), an artificial sweetening agent, was studied. It was also studied for its carcinogenic potential.

애플리케이션

• Gabapentin-saccharin co-crystals with enhanced physicochemical properties and in vivo absorption formulated as oro-dispersible tablets.: This study presents the formulation of gabapentin-saccharin co-crystals, demonstrating improved solubility and absorption, beneficial for pharmaceutical applications (Soliman et al., 2020, doi: 10.1080/10837450.2019.1687521).


• Improving the solubility, dissolution, and bioavailability of Ibrutinib by preparing it in a coamorphous state with saccharin.: The research focuses on enhancing the bioavailability of Ibrutinib through coamorphous preparation with saccharin, which is significant for cancer treatment (Shi et al., 2019, doi: 10.1016/j.xphs.2019.04.031).

생화학적/생리학적 작용

A sweet tastant for mammals. A glycerol taste receptor binding site specific for glucose has been proposed in drosophila.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)