363960

(S,R)-Noscapine

97%

• 동의어(들): α-Narcotine, (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone
• 실험식(Hill 표기법): C₂₂H₂₃NO₇
• CAS Number: 128-62-1
• Molecular Weight: 413.42
• EC Number: 204-899-2
• MDL number: MFCD00069316
• UNSPSC 코드: 12352005
• PubChem Substance ID: 24862408
• NACRES: NA.22

속성

• Quality Level: 100
• 분석: 97%
• 양식: solid
• 광학 활성: [α]20/D −200°, c = 1 in chloroform
• mp: 174-176 °C (lit.)
• 작용기: ester
• SMILES string: COc1ccc2C(OC(=O)c2c1OC)C3N(C)CCc4cc5OCOc5c(OC)c34
• InChI: 1S/C22H23NO7/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18/h5-6,9,17-18H,7-8,10H2,1-4H3/t17-,18+/m1/s1
• InChI key: AKNNEGZIBPJZJG-MSOLQXFVSA-N

설명

일반 설명

(S,R)-Noscapine is a phthalideisoquinoline alkaloid found in opium. It is an antimicrotubule agent that also shows potent antitumor activity.

애플리케이션

Noscapine may be used as a source to synthesize its bromo-derivatives, which has higher tubulin binding activity when compared to noscapine. Its 3,4,5-trimethoxybenzyl analog is a potential antitumor agent.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H336
• 예방조치 성명서: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral - STOT SE 3
• 표적 기관: Central nervous system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves