68255

4-Methyl-2-oxovaleric acid

≥98.0% (T)

• 동의어(들): α-Ketoisocaproic acid, 2-Oxoisocaproic acid, 4-Methyl-2-oxopentanoic acid, Ketoleucine
• Linear Formula: (CH₃)₂CHCH₂COCOOH
• CAS Number: 816-66-0
• Molecular Weight: 130.14
• Beilstein: 1701823
• EC Number: 212-435-5
• MDL number: MFCD00066204
• UNSPSC 코드: 12352100
• PubChem Substance ID: 57652142
• NACRES: NA.22

속성

• 분석: ≥98.0% (T)
• refractive index: n20/D 1.431
• bp: 82-83 °C/11 mmHg (lit.)
• mp: 8-10 °C
• density: 1.055 g/mL at 20 °C (lit.)
• 작용기: carboxylic acid; ketone
• 저장 온도: 2-8°C
• SMILES string: CC(C)CC(=O)C(O)=O
• InChI: 1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)
• InChI key: BKAJNAXTPSGJCU-UHFFFAOYSA-N

설명

일반 설명

4-Methyl-2-oxovaleric acid, also known as α-ketoisocaproic acid (KIC), is a metabolite of leucine. It is commonly used as a building block in the synthesis of leucine and its derivatives, and it plays a role in amination reactions and asymmetric synthesis. Additionally, KIC serves as an intermediate in the formation of Strecker aldehydes.

애플리케이션

• Role in Human Brain Ketometabolism: 4-Methyl-2-oxovaleric acid has been implicated in the temporal patterns of ketometabolism in cerebral microdialysis fluids of patients with traumatic brain injury, underscoring its significance in biochemical pathways within the brain (Eiden et al., 2019).

안전성 정보

• 픽토그램: GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H314
• 예방조치 성명서: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Hazard Classifications: Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter