74540

Nordihydroguaiaretic acid

≥97.0% (HPLC)

• 동의어(들): 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane, 4,4′-(2,3-Dimethyltetramethylene)dipyrocatechol, Masoprocol, NDGA
• Linear Formula: [-CH(CH₃)CH₂C₆H₃-1,2-(OH)₂]₂
• CAS Number: 500-38-9
• Molecular Weight: 302.36
• Beilstein: 2056826
• EC Number: 207-903-0
• MDL number: MFCD00002206
• UNSPSC 코드: 12352100
• PubChem Substance ID: 57652455
• NACRES: NA.22

속성

• 분석: ≥97.0% (HPLC)
• 양식: crystals
• 불순물: ≤2% water
• mp: 184-186 °C (lit.)
• SMILES string: CC(Cc1ccc(O)c(O)c1)C(C)Cc2ccc(O)c(O)c2
• InChI: 1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
• InChI key: HCZKYJDFEPMADG-UHFFFAOYSA-N
• 유전자 정보: mouse ... Alox12(11684)

설명

일반 설명

Nordihydroguaiaretic acid (NDGA) is used as an antioxidant and potent scavenger of reactive oxygen species (ROS).

애플리케이션

Nordihydroguaiaretic acid can be used:

• In the synthesis of nordihydroguaiaretic acid derivatives with potent HIV inhibition activity.
• As a starting material in the synthesis of tetra-O-methylnordihydroguaiaretic acid.

생화학적/생리학적 작용

Lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure.

기타 정보

Inhibitor of broad bean lipoxygenase

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H315,H319,H335
• 예방조치 성명서: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves