927732
C5 Lenalidomide-difluoroPEG1-C4-piperazine Hydrochloride
≥95%
동의어(들):
2-(2,2-Difluoro-3-(4-(piperazin-1-yl)butoxy)propoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)acetamide Hydrochloride
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C26H35F2N5O6 · xHCl
Molecular Weight:
551.58 (free base basis)
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.22
ligand
C5 Lenalidomide
Quality Level
분석
≥95%
양식
powder
저장 온도
2-8°C
SMILES string
O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(COCC(F)(F)COCCCCN4CCNCC4)=O)=CC=C31.Cl
InChI
1S/C26H35F2N5O6.ClH/c27-26(28,16-38-12-2-1-9-32-10-7-29-8-11-32)17-39-15-23(35)30-19-3-4-20-18(13-19)14-33(25(20)37)21-5-6-22(34)31-24(21)36;/h3-4,13,21,29H,1-2,5-12,14-17H2,(H,30,35)(H,31,34,36);1H
InChI key
NWCOGWMYGNQKPZ-UHFFFAOYSA-N
애플리케이션
Protein degrader building block C5 Lenalidomide-difluoroPEG1-C4-piperazine Hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a fluorinated linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Targeted Protein Degradation
Targeted Protein Degradation
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Repr. 2 - STOT RE 2
표적 기관
Blood
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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